Biosimilar competition: molecules, markets and developers

How many biosimilars exist for each molecule, in how many markets, and who makes them.

This page shows how many biosimilars exist for each molecule, and in how many of the seven markets.

The first table lists the molecules with the most competition. Adalimumab, denosumab, pegfilgrastim and bevacizumab have more than fifteen products each, approved in all seven markets. Any new product for these molecules will compete on price and on having every strength and presentation.

The second table lists the molecules with the fewest competition. Some have only one or two biosimilars, and several markets with none. These are the molecules where a new company still has room.

Further down, the same counts are grouped by therapeutic area, and the last two tables rank the markets and the developers by their number of approved products.

One note on the counts. A product sold under several names is counted once. The page does not cover sales, prices or patents. A crowded molecule can still be a good choice and an open one a poor one, depending on which markets a company can reach and what it can manufacture. EvySaif helps companies work that out.

Molecules with the most competition

MoleculeApproved productsDevelopersMarketsUnder reviewRecords
Bevacizumab
Oncology
19177/7249
Adalimumab
Immunology
18187/7·54
Pegfilgrastim
Hematology
18187/7244
Denosumab
Endocrinology
17177/7393
Teriparatide
Endocrinology
16145/7·23
Ranibizumab
Ophthalmology
15147/7·28
Trastuzumab
Oncology
13137/7·42
Ustekinumab
Immunology
13137/7·43
Aflibercept
Ophthalmology
13136/7·38
Filgrastim
Hematology
12127/7131

Molecules with the fewest competition

MoleculeApproved productsDevelopersMarketsUnder reviewRecords
Agalsidase beta
Rare disease
111/7·1
Natalizumab
Neurology
113/7·3
Eculizumab
Rare disease
223/7·7
Interferon alfa-2b
Infectious disease
331/7·4
Omalizumab
Immunology
336/729
Pertuzumab
Oncology
444/728
Insulin lispro
Diabetes
435/7·7
Golimumab
Immunology
445/7·7
Follitropin alfa
Fertility
554/7·8
Insulin aspart
Diabetes
557/7217

No approved biosimilar yet in any of the seven markets: abatacept, vedolizumab.

By therapeutic area

Approved products per molecule, grouped by area.

Diabetes

Endocrinology

Fertility

Hematology

Immunology

Infectious disease

Neurology

Oncology

Ophthalmology

Rare disease

Most active markets

MarketApproved productsMolecules
CDSCO India11126
EMA European Union11026
MHRA United Kingdom11026
FDA United States8921
HC Canada7021
PMDA Japan4723
EDE United Arab Emirates3517

Most active developers

Companies ranked by the number of their products with at least one approval in the seven markets.

DeveloperApproved productsMolecules
Reliance Life Sciences
India
1414
Intas Pharmaceuticals
India
1212
Zydus Lifesciences
India
1111
Sandoz
Switzerland
1010
Samsung Bioepis
South Korea
1010
Celltrion
South Korea
1010
Biocon Biologics
India
99
Amgen
United States
88
Pfizer
United States
77
Enzene Biosciences
India
66
Dr. Reddy's Laboratories
India
66
Lupin
India
66
Fresenius Kabi
Germany
55
Alvotech
Iceland
55
Hetero
India
55

Choosing between a crowded molecule and an open one is a regulatory and market-access question as much as a commercial one. EvySaif prepares that assessment for developers. Regulatory strategy consulting

Evaluating a biosimilar opportunity?

EvySaif can help assess your regulatory pathway, clinical evidence requirements and market-entry strategy across India, UAE and other target markets.

Talk to a biosimilar regulatory consultant
Data current to September 2026.