Clinician-Led Scientific Partner

Turning Clinical Data into Evidence That Earns Trust

Accurate. Compliant. Insightful. EvySaif partners with pharma, biotech, and device teams for scientific writing, regulatory submissions, HEOR, and medical affairs that stand up to regulators, payers, and peer review.

Built to global standards
US FDAEMACDSCOICH GCPCHEERS 2022EU MDR / IVDR
Evidence pipeline
Data Trials, literature, RWE Evidence CSRs, models, reviews Submission Dossiers, responses Approval and access
What We Do

Five practices, one standard of evidence

From first protocol to post-approval value, every deliverable is built by the same clinician-led team to the standards regulators, payers, and journals expect.

01 · HEOR

Health Economics and Outcomes Research

Economic models, systematic evidence, and value dossiers that make the case for access, reported to CHEERS 2022 and PRISMA 2020 and built for HTA, pricing, and reimbursement decisions.

Cost-effectiveness modelingBudget impact analysisSLR & meta-analysisReal-world evidenceHTA & value dossiers
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02 · Medical Writing

Scientific and Medical Writing

Clinical and regulatory documents written to ICH standards, from trial protocols and CSRs to pharmacovigilance reports and submission summaries, accurate to the data and clear to the reviewer.

Clinical trial protocolsClinical study reportsDSUR / PSUR / PBRERCTD & eCTD summaries
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03 · Devices & IVD

Medical Devices and IVD

CE and CDSCO pathways handled end to end, clinical and performance evaluation, MDR and IVDR technical documentation, and post-market evidence that keeps your device compliant after launch.

CER & PEP / PERMDR / IVDR technical filesStudy protocolsPMS, PMCF & PMPFCE & CDSCO strategy
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04 · Regulatory Affairs

Regulatory Affairs

Submission strategy, dossier preparation, and authority responses across the markets you sell in, with direct experience of Indian, US, European, and Gulf regulatory expectations.

CDSCO (India)US FDAEMA & EUSFDA (Saudi Arabia)UAE
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05 · Medical Affairs

Medical Affairs

Non-promotional scientific exchange delivered compliantly, from medical information and advisory boards to MSL enablement and medical review, as an extension of your own team.

Medical informationAdvisory boardsMSL enablementMedical reviewEvidence planning
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Health Economics and Outcomes Research

We turn clinical data into economic evidence

EvySaif designs and builds decision analytic models end to end, from model structure and inputs to probabilistic sensitivity analysis and CHEERS 2022 compliant reporting, ready for journals, payers, and HTA bodies.

Decision trees Markov models Budget impact analysis PSA and CEAC Value dossiers Systematic reviews
Model 01

Decision tree analysis

For short horizon comparisons, we structure the decision problem, assign pathway probabilities, and attach costs and outcomes to every terminal node.

  • Comparator mapping and pathway design
  • Probability and cost inputs from literature or trial data
  • Expected value roll back and sensitivity analysis
Decision tree
Decision New intervention Standard of care p = 0.68 p = 0.32 p = 0.49 p = 0.51 Response Cost 8,420 QALY 0.86 No response Cost 11,960 QALY 0.61 Response Cost 5,310 QALY 0.79 No response Cost 9,140 QALY 0.54
Model 02

Markov cohort model

For chronic and progressive disease, we build state transition models over lifetime horizons, with transition probabilities, cycle costs, and utilities for every health state.

  • Health state definition and transition matrix
  • Half cycle correction and discounting
  • Probabilistic sensitivity analysis and CEAC
Markov cohort
Progression free Progressed Death p = 0.15 p = 0.04 p = 0.18 p = 0.81 p = 0.82 p = 1.00 Annual cycles, lifetime horizon, 3.5 percent discounting
Model 03

Probabilistic sensitivity analysis

Every input carries uncertainty. We run Monte Carlo simulations across full parameter distributions so decision makers can see how robust the result really is.

  • Distributions assigned to every parameter
  • 1,000 plus iteration Monte Carlo simulation
  • Cost effectiveness plane and acceptability curves
Monte Carlo PSA
0.2 0.4 0.6 0.8 8k 16k Incremental QALYs Incremental cost WTP 20,000 per QALY 98.7 percent of iterations cost effective 1,000 Monte Carlo iterations on the cost effectiveness plane
Model output
ICER 0 per QALY gained
PSA verified CHEERS 2022 compliant HTA ready

Every model is delivered with a full technical report, transparent assumptions, and sensitivity analyses that stand up to peer review and payer scrutiny.

Discuss your HEOR project
Led by clinicians with peer reviewed cost effectiveness publications
Medical Devices and IVD

From classification to approval, and everything after

EvySaif supports medical device and IVD manufacturers end to end, from clinical evaluation and technical documentation to post-market surveillance, built to the expectations of EU notified bodies, the US FDA, and CDSCO reviewers alike.

CER · MEDDEV 2.7/1 Rev 4 PEP & PER for IVDs MDR / IVDR technical files PMS · PMCF · PMPF CE marking strategy CDSCO registration US FDA pathways Clinical & performance study protocols Global regulatory submissions
Stage 01

Clinical evaluation

We plan and write clinical evaluations to MDR Annex XIV and MEDDEV 2.7/1 Rev 4, from scope and state of the art to appraisal of every clinical data source. The same discipline carries into US FDA and CDSCO submissions.

  • CEP scoping and state of the art review
  • Literature appraisal and equivalence justification
  • Clinical investigation and performance study protocols
  • Benefit-risk conclusions mapped to GSPRs
Clinical evaluation
Scientific literature Equivalence data Clinical investigation & PMCF Appraise & analyse CER GSPR mapped Clinical evaluation per MDR Annex XIV and MEDDEV 2.7/1 Rev 4
Stage 02

Technical documentation

We build and remediate technical documentation to MDR and IVDR Annex II and III, structured the way notified bodies expect to review it, with every claim traceable to evidence.

  • Annex II / III structure and gap assessment
  • GSPR checklist with evidence mapping
  • Risk management aligned to ISO 14971
Technical file
Technical file · Annex II & III Device description & intended purpose Design & manufacturing information Risk management · ISO 14971 Verification & validation evidence GSPR checklist 0% Every technical file claim traced to its evidence
Stage 03

The post-market loop

Approval is the start, not the finish. We run the post-market evidence cycle and feed it back into the clinical evaluation and risk file, keeping your documentation audit-ready for the device lifetime.

  • PMS plans, PMS reports and PSURs
  • PMCF / PMPF studies and evaluation reports
  • CER and risk file updates every cycle
Post-market surveillance
Market data PMS analysis PMCF evidence CER & risk update Device lifetime audit-ready, every cycle PMS, PMCF and vigilance feeding the CER and risk file continuously
Regulatory outcome

One technical file, defensible end to end

EU MDR 2017/745 EU IVDR 2017/746 CDSCO MDR 2017 US FDA ISO 14971 aligned

From first classification call to the latest PSUR, every document is written by the same clinician-led team, so your evidence tells one consistent story to any reviewer who opens the file.

Discuss your device pathway
Hands-on experience across EU notified body, US FDA, and CDSCO submissions
What Sets Us Apart

Why Choose EvySaif

We help pharma, biotech, and healthcare teams turn complex science into credible, compliant, and impactful communication.

Scientific Rigor

Every deliverable is built on validated evidence, transparent referencing, and strict adherence to global reporting guidelines.

Therapeutic Expertise

Oncology, infectious diseases, cardiology, rare diseases, and metabolic disorders. We bring domain depth that shows in every document.

Visual Impact

High quality graphics, infographics, and data visualizations that make complex science easy to grasp at a glance.

Clear & Engaging Storytelling

We translate complex data into clear, persuasive narratives that resonate with regulators, clinicians, and patients alike.

Partnership Approach

We work as an extension of your medical affairs team, with full ownership, reliability, and open communication at every step.

Timely & Reliable Delivery

We understand pharma timelines and deliver with efficiency, consistency, and on-time execution, every single time.

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Scientific & medical projects delivered
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Client satisfaction achieved
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Years experience in medical communication
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Hours dedicated to research & scientific writing

A track record, not just capability

Delivered work our clients can verify, not claims

First-in-human clinical trial protocols authored and approved

IVD performance evaluation files delivered for Indian and European markets

Peer-reviewed publications behind the writing, including first-author research

Oncology advisory board programs designed and delivered end to end

FAQ

Frequently Asked Questions

We partner with pharmaceutical and biotech companies, medical device and IVD manufacturers, CROs, and healthcare organizations across India, MENA, and Europe, from early-stage teams to established medical affairs departments.

Yes. Alongside the writing, we design publication-ready figures, infographics, slide decks, and data visualizations that make complex science easy to grasp at a glance.

Yes. Our expertise spans Oncology, Infectious Diseases, Cardiology, Metabolic Disorders, and more.

Every deliverable is built by clinician-led writers on validated evidence, with transparent referencing and adherence to ICH GCP, GPP 2022, and the relevant reporting guidelines, then passed through independent quality review before delivery.

Absolutely. We provide regulatory writing, scientific publications, medical affairs content, and educational materials.

Reach out through the contact page or email info@evysaif.com. We start with a short discovery call, scope the deliverable together, and share a proposal with timelines, typically within two business days.

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