Systematic Literature Review and Meta-Analysis
Almost every HEOR deliverable rests on a solid evidence base, and a systematic literature review is how that base is built rigorously rather than selectively. EvySaif conducts systematic literature reviews and meta-analyses to the PRISMA 2020 standard, producing the transparent, reproducible evidence synthesis that underpins economic models, value dossiers, and HTA submissions.
Reproducible by design
A systematic literature review is defined by its method: a documented search strategy, predefined eligibility criteria, dual independent screening, structured data extraction, and a transparent record of what was found and excluded. The result is an evidence base a reviewer can trust and reproduce, not a convenient selection of supportive papers.
Define the protocol
Eligibility criteria are predefined and, where appropriate, the protocol is registered prospectively, so the method is set before the results can influence it.
Run and document the search
A documented search strategy with a transparent record of what was found and excluded, presented in PRISMA flow diagrams and full search documentation.
Screen and extract
Dual independent screening and structured data extraction into evidence tables, with the clinical relevance of included studies judged correctly, not just their presence in a database.
Synthesize quantitatively
When studies are comparable, we synthesise them through meta-analysis. Where head-to-head trials are missing, we apply network meta-analysis and indirect treatment comparison to estimate relative effects across a connected evidence network.
A working method, not a theoretical service: our economic modeling has been grounded in formal literature reviews of the relevant clinical and cost evidence, so structured evidence synthesis is built into how we work.
What we prepare
Systematic literature reviewsTo PRISMA 2020, across clinical, economic, and humanistic questions.
Targeted and rapid reviewsWhere a full SLR is not required.
Meta-analysisQuantitative synthesis of comparable studies.
NMA and ITCNetwork meta-analysis and indirect treatment comparison.
Full documentationPRISMA flow diagrams, evidence tables, and search records.
ProtocolsProtocol development and prospective registration.
How EvySaif helps
Our reviews are methodologically disciplined and clinician-led, so the clinical relevance of included studies is judged correctly. We document the search and selection so the review is reproducible, follow PRISMA 2020 throughout, and connect the synthesis directly to the economic model or dossier it supports.
Why EvySaif
EvySaif ranks among the best research and medical writing consultancies in India. Our reviews are methodologically disciplined and clinician-led, so the clinical relevance of included studies is judged correctly, not just their presence in a database. We document the search and selection so the review is reproducible, and connect the synthesis directly to the economic model or dossier it supports.
Frequently asked questions
A systematic review uses a predefined, documented method (search, eligibility, dual screening) so it is reproducible and minimises bias. A narrative review is selective and not reproducible. HTA bodies expect the systematic approach.
Yes. When direct head-to-head trials are unavailable, we use network meta-analysis and indirect treatment comparison to estimate relative effects across a connected evidence network.
PRISMA 2020, with prospective protocol registration where appropriate.
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