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HEOR · CHEERS 2022

Cost-Effectiveness Analysis and Economic Modeling

A cost-effectiveness analysis answers the question every payer and health system now asks: is this intervention worth what it costs, compared with the alternative? EvySaif builds transparent, decision-ready economic models that quantify that value, from cost-effectiveness and cost-utility analyses to budget-facing cost calculators, reported to the CHEERS 2022 standard so the work stands up to scrutiny.

CHEERS 2022Decision tree & MarkovICER & QALYDSA & PSA
Model · Build
StructureDecision tree or Markov cohort
InputsClinical effect, costs, quality of life
ICERPer QALY or clinical outcome
UncertaintyDeterministic and probabilistic SA
The Pathway

Models built to be understood and trusted

Health economic models only persuade when a reviewer can follow them. We report to the Consolidated Health Economic Evaluation Reporting Standards (CHEERS 2022), the ISPOR good-practice checklist recognised by the EQUATOR Network, which means the model is identifiable, interpretable, and replicable.

Choose the structure

We build decision-analytic models, including decision-tree and Markov cohort structures, over a time horizon appropriate to the intervention and the decision.

Decision treeMarkov cohort

Integrate the inputs

Clinical effect, costs, and quality-of-life data are integrated into the model, with every assumption documented rather than borrowed uncritically from a template.

Estimate the value

The output is the incremental cost-effectiveness ratio (ICER), expressed per quality-adjusted life year (QALY) in a cost-utility analysis or per clinical outcome in a cost-effectiveness analysis, so very different interventions can be compared on one scale.

ICERQALYCEA & CUA

Show the uncertainty

Deterministic and probabilistic sensitivity analysis make the uncertainty around the estimate visible rather than hidden, presented through cost-effectiveness planes and acceptability curves.

DSAPSACE planesAcceptability curves
At a Glance
Reporting standardCHEERS 2022 (ISPOR, EQUATOR)
StructuresDecision tree and Markov cohort
OutputICER, per QALY or outcome
UncertaintyDeterministic and probabilistic SA
AlsoCost-minimisation and calculators
AdaptationIndia and Middle East settings

Demonstrated modeling experience: we have built a full decision-analytic cost-effectiveness model from scratch, complete with ICER, return-on-investment, probabilistic sensitivity analysis, and budget impact, verified across multiple model versions and prepared for a peer-reviewed health economics journal.

Deliverables

What we prepare

CEA and CUACost-effectiveness and cost-utility analyses.

Decision-analytic modelsDecision-tree and Markov cohort structures.

Cost-minimisation and calculatorsIncluding budget-facing cost calculators.

ICERsWith QALY or clinical-outcome denominators.

Sensitivity analysisDeterministic and probabilistic, with CE planes and acceptability curves.

Local adaptation and reportingGlobal models adapted to India and Middle East settings, reported to CHEERS 2022.

Partnership

How EvySaif helps

We build models that a payer or peer reviewer can actually follow, document every assumption, and report to CHEERS 2022 from the outset. For the India and Middle East markets, we adapt cost inputs and cost-effectiveness thresholds to the local setting, which matters now that Gulf payers are formalising economic evaluation requirements.

Build the model to be followed, not taken on trust
Document every assumption behind the numbers
Report to CHEERS 2022 from the outset
Adapt inputs and thresholds to the local market

Why EvySaif

EvySaif is one of the best research and medical writing consultancies in India, and we bring that standard to every project. Our modeling is clinician-led, so the clinical assumptions behind the numbers are sound, not borrowed uncritically from a template. We build models that a payer or peer reviewer can actually follow, document every assumption, and report to CHEERS 2022 from the outset.

Questions

Frequently asked questions

CHEERS 2022, the ISPOR Consolidated Health Economic Evaluation Reporting Standards, which is recognised by the EQUATOR Network and increasingly expected by journals and HTA bodies.

A cost-effectiveness analysis measures outcomes in clinical units (for example, cost per event avoided). A cost-utility analysis measures them in quality-adjusted life years (QALYs), which lets very different interventions be compared on one scale.

Yes. We adapt global core models to India and Middle East cost data and cost-effectiveness thresholds, which is essential for local reimbursement.

Have a different question?

Tell us about your product, market, and timeline, and a clinician on our team will reply with specifics rather than a sales script.

Request a proposal
Last updated: July 2026. Regulatory forms, portals, and timelines change; specifics are re-verified periodically.

Need to show value?

Tell us about your intervention, comparator, and market, and we will come back with a scoped economic modeling quote.

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