Zvogra / Kefdensis / Xbonzy / Acvybra
Denosumab biosimilar developed by Alvotech, development code AVT03. Reference product Prolia and Xgeva.
Brands by market: Zvogra and Kefdensis (EU, Stada); Xbonzy and Acvybra (EU, Reddy Holding) · Commercial partner or holder: Stada (EU); Dr. Reddy's (EU)
FDAnot listed
EMANov 2025authorised
CDSCOnot listed
EDEnot listed
Status by market
FDA
United States
Not listed by FDA.
EMA
European Union · Zvogra
European Medicines Agency and European CommissionApprovedBrand
Zvogra
Holder or applicant
Stada Arzneimittel AG
Pathway
Centralised (Article 10(4))
Approved
Nov 2025
Application or permission
EMEA/H/C/006552
Presentations
see SmPC
Source
S017
EMA
European Union · Kefdensis
European Medicines Agency and European CommissionApprovedBrand
Kefdensis
Holder or applicant
Stada Arzneimittel AG
Pathway
Centralised (Article 10(4))
Approved
Nov 2025
Application or permission
EMEA/H/C/006490
Presentations
see SmPC
Source
S017
EMA
European Union · Xbonzy
European Medicines Agency and European CommissionApprovedBrand
Xbonzy
Holder or applicant
Reddy Holding GmbH
Pathway
Centralised (Article 10(4))
Approved
Nov 2025
Application or permission
EMEA/H/C/006722
Presentations
see SmPC
Source
S017
EMA
European Union · Acvybra
European Medicines Agency and European CommissionApprovedBrand
Acvybra
Holder or applicant
Reddy Holding GmbH
Pathway
Centralised (Article 10(4))
Approved
Nov 2025
Application or permission
EMEA/H/C/006734
Presentations
see SmPC
Source
S017
CDSCO
India
Not listed by CDSCO.
EDE
United Arab Emirates
Not listed by EDE.
Chronology
- EMANov 2025Authorised by the European Commission as Acvybra
- EMANov 2025Authorised by the European Commission as Kefdensis
- EMANov 2025Authorised by the European Commission as Xbonzy
- EMANov 2025Authorised by the European Commission as Zvogra
Sources
S017EMA, medicines data table (medicines-output-medicines-report_en.xlsx) Primary (regulator)
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