Tyenne

Tocilizumab biosimilar developed by Fresenius Kabi, development code MSB11456. Reference product Actemra (RoActemra in the European Union).

Brands by market: Tyenne (USA, EU) · Commercial partner or holder: Fresenius Kabi
FDAMar 2024approved
EMASep 2023authorised
CDSCOnot listed
EDEnot listed

Status by market

FDA

United States · Tyenne

US Food and Drug AdministrationApproved
Brand
Tyenne
Holder or applicant
Fresenius Kabi USA, LLC
Pathway
351(k)
Approved
Mar 2024
Application or permission
761275
Licence type
351(k) biosimilar, not interchangeable
Presentations
80 mg/4 mL, 200 mg/10 mL, 400 mg/20 mL vials; 162 mg/0.9 mL SC (BLA 761449, March 2025)
Source
S001, S016
EMA

European Union · Tyenne

European Medicines Agency and European CommissionApproved
Brand
Tyenne
Holder or applicant
Fresenius Kabi Deutschland GmbH
Pathway
Centralised (Article 10(4))
Approved
Sep 2023
Application or permission
EMEA/H/C/005781
Indications as licensed
RA, GCA, sJIA, pJIA, CRS, COVID-19
Presentations
see SmPC
Note
First EU tocilizumab biosimilar.
Source
S017
CDSCO

India

Not listed by CDSCO.

EDE

United Arab Emirates

Not listed by EDE.

Chronology

Sources

All tocilizumab biosimilars

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Data current to September 2026.