Systematic Literature Review and Meta-Analysis
Almost every HEOR deliverable rests on a solid evidence base, and a systematic literature review is how that base is built rigorously rather than selectively. EvySaif conducts systematic literature reviews and meta-analyses to the PRISMA 2020 standard, producing the transparent, reproducible evidence synthesis that underpins economic models, value dossiers and HTA submissions.
- Reproducible by design
A systematic literature review is defined by its method: a documented search strategy, predefined eligibility criteria, dual independent screening, structured data extraction, and a transparent record of what was found and excluded. We follow PRISMA 2020, the recognised reporting standard, and where appropriate register the protocol prospectively. When studies are comparable, we synthesise them quantitatively through meta-analysis, and where head-to-head trials are missing, we apply network meta-analysis and indirect treatment comparison to estimate relative effects. The result is an evidence base a reviewer can trust and reproduce, not a convenient selection of supportive papers.
- What we deliver
- Systematic literature reviews (SLRs) to PRISMA 2020
- Clinical, economic and humanistic (quality-of-life) SLRs
- Targeted and rapid literature reviews where a full SLR is not required
- Meta-analysis of comparable studies
- Network meta-analysis (NMA) and indirect treatment comparison
- PRISMA flow diagrams, evidence tables and full search documentation
- Protocol development and prospective registration
- Demonstrated experience
Structured evidence synthesis is built into how we work. Our economic modeling has been grounded in formal literature reviews of the relevant clinical and cost evidence, so we approach SLRs as a working method, not a theoretical service.
- Who it is for
Manufacturers building value dossiers and HTA submissions, teams that need an evidence base for an economic model, and researchers requiring a publication-ready systematic review or meta-analysis.
- Why EvySaif
EvySaif ranks among the best research and medical writing consultancies in India. Our reviews are methodologically disciplined and clinician-led, so the clinical relevance of included studies is judged correctly, not just their presence in a database. We document the search and selection so the review is reproducible, follow PRISMA 2020 throughout, and connect the synthesis directly to the economic model or dossier it supports.
- Frequently asked questions
What is the difference between a systematic literature review and a narrative review?
A systematic review uses a predefined, documented method (search, eligibility, dual screening) so it is reproducible and minimises bias. A narrative review is selective and not reproducible. HTA bodies expect the systematic approach.
Do you perform network meta-analysis?
Yes. When direct head-to-head trials are unavailable, we use network meta-analysis and indirect treatment comparison to estimate relative effects across a connected evidence network.
Which reporting standard do you use?
PRISMA 2020, with prospective protocol registration where appropriate.